Gastrokines and derived peptides including inhibitors

Details Gastrokines and derived peptides including inhibitors Gastrokines and derived peptides including inhibitors

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/18 (2006.01) C07K 7/04 (2006.01) C07K 14/475 (2006.01) C07K 16/22 (2006.01) C12N 5/071 (2010.01)

Patent

CA 2442635

A novel group of gastrokines called Gastric Antrum Mucosal Protein is characterized. A member of the group is designed AMP-18. AMP 18 genomic DNA, cDNA and the AMP- 18 protein are sequenced for human, mouse and pig. The AMP- 18 protein and active peptides derived from it are cellular growth factors. Surprisingly, peptides capable of inhibiting the effects of the complete protein, are also derived from the AMP- 18 protein. Control of mammalian gastro-intestinal tissues growth and repair is facilitated by the use of the proteins, making the proteins candidates for therapies.

L'invention concerne un nouveau groupe de gastrokines appelé protéine de la muqueuse antro-pylorique. Un membre de ce groupe est désigné sous la forme AMP-18. L'ADN génomique AMP-18, l'ADN complémentaire AMP-18 et la protéine AMP-18 sont séquencés pour l'être humain, la souris et le porc. La protéine AMP-18 et des peptides actifs dérivés de celle-ci constituent des facteurs de croissance cellulaire. De façon surprenante, les peptides pouvant inhiber les effets de la protéine complète sont également dérivés de la protéine AMP-18. L'utilisation de ces protéines facilite la régulation de la croissance et de la réparation des tissus gastro-intestinaux chez les mammifères et est par conséquent envisageable à des fins de traitement.

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