Gata-6 transcription factor: compositions and methods

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2264485

Methods and compositions for reducing or preventing the proliferation of vascular smooth muscle cells are provided. The method involves the step of administering an isolated GATA-6 molecule to a subject to prevent or reduce vascular smooth muscle cell proliferation. The isolated GATA-6 molecule can be a GATA-6 nucleic acid or a GATA-6 protein.

L'invention concerne des méthodes et des compositions permettant de diminuer ou de prévenir la prolifération des muscles lisses de la paroi vasculaire. Selon la méthode, on administre à un sujet une molécule de GATA-6 isolée afin de prévenir ou de diminuer la prolifération des muscles lisses de la paroi vasculaire. La molécule de GATA-6 isolée peut être un acide nucléique GATA-6 ou une protéine GATA-6.

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