Gatifloxacin-containing aqueous liquid preparation

Details Gatifloxacin-containing aqueous liquid preparation Gatifloxacin-containing aqueous liquid preparation

A - Human Necessities

61

K

A61K 31/496 (2006.01) A61P 27/02 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2718826

There is provided an aqueous liquid preparation comprising Gatifloxacin or a pharmacologically acceptable salt thereof or a hydrate thereof, phosphoric acid or a salt thereof, and xanthan gum, wherein a pH thereof is 5.5 or more and less than 7Ø The aqueous liquid preparation has improved intraocular penetration of Gatifloxacin. Further, the formation of a precipitate during storage at a lower temperature and at the time of freezing and thawing of the aqueous liquid preparation is suppressed by incorporating at least one of the ingredient selected from the group consisting of nicotinamide, caffeine, methylglucamine, methyl parahydroxybenzoate and a salt thereof into the aqueous liquid preparation.

L'invention concerne un liquide aqueux contenant de la gatifloxacine, un sel de celle-ci pharmacologiquement acceptable ou un hydrate de gatifloxacine ou un sel de celui-ci pharmacologiquement acceptable, un acide phosphorique ou un sel de celui-ci, et de la gomme de xanthane. Ce liquide possède une valeur de pH d'au moins 5,5 et inférieure à 7. Il présente une pénétration intraoculaire de gatifloxacine améliorée. Lorsqu'au moins un élément sélectionné parmi l'acide nicotinique, l'amide, la caféine, la méthylglucamine, le paraoxybenzoate de méthyle et leurs sels sont ajoutés au liquide aqueux, la production de précipités dans le liquide aqueux durant le stockage du liquide à basse température ou lors de la congélation/décongélation dudit liquide peut être évitée.

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