Gb virus b based replicons and replicon enhanced cells

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/86 (2006.01) C07K 14/18 (2006.01) C12N 7/00 (2006.01)

Patent

CA 2472759

The present invention features GBV-B replicons and replicon enhanced cells. A GBV-B replicon is an RNA molecule able to autonomously replicate in a cultured cell and produce detectable levels of one or more GBV-B proteins. GBV-B replicon enhanced cells are cells having an increased ability to maintain a GBV-B replicon.

L'invention concerne des réplicons du GBV-B ainsi que des cellules renforcées pour des réplicons. Un réplicon du GBV-B est une molécule d'ARN pouvant se répliquer de façon autonome dans une cellule cultivée et produire des taux détectables d'une ou de plusieurs protéines de GBV-B. Les cellules renforcées pour les réplicons du GBV-B sont des cellules présentant une aptitude accrue à entretenir un réplicon du GBV-B.

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