Gd2 ligands

Details Gd2 ligands Gd2 ligands

C - Chemistry, Metallurgy

07

K

C07K 7/04 (2006.01) A61K 38/04 (2006.01) C07K 7/64 (2006.01)

Patent

CA 2538719

The invention provides ligands of ganglioside GD2, including peptide ligands such as GGITNYNSALM; YCGGITNYNSACY; YCITNYNSCY; YCGGITNYNCY; YCTNYGVHCY; YCTNYGVCY; GGIANYNTS; YCGGIANYNCY; YCGGIANYNTSCY; and, YCIANYNTCY. GD2 ligands of the invention may for example be used to treat or diagnose diseases such as cancers in which cells express GD2, including neuroblastomas.

L'invention concerne des ligands de ganglioside GD2, dont des liants peptidiques tels que GGITNYNSALM; YCGGITNYNSACY; YCITNYNSCY; YCGGITNYNCY; YCTNYGVHCY; YCTNYGVCY; GGIANYNTS; YCGGIANYNCY; YCGGIANYNTSCY; et YCIANYNTCY. Les ligands de GD2 de l'invention peuvent être utiliser notamment pour le traitement ou le diagnostic de maladies tels que des cancers dans lesquelles des cellules expriment GD2, tels que des neuroblastomes.

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