Gel filtration of heat treated factor viii

C - Chemistry – Metallurgy – 07 – K

Patent

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195/39, 195/72

C07K 14/755 (2006.01) A61K 38/37 (2006.01) C07K 1/36 (2006.01) C12N 7/04 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2017039

Highly purified antihemophilic factor is produced by a process comprising a PEG precipitation step, a gel filtration step and a heat treating virus inactivation step. Al(OH)3 adsorption and PEG precipitation carried out at room temperature allow processing to proceed directly to a gel filtration step.

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