Gel formulations and uses thereof

Details Gel formulations and uses thereof Gel formulations and uses thereof

G - Physics

01

N

G01N 33/50 (2006.01) A61L 31/14 (2006.01) C11D 3/37 (2006.01)

Patent

CA 2571695

The present invention provides the use of a composition comprising a block polymer as a support matrix in the manipulation, processing or analysis of particles, such as cells and fluorescent beads. In a preferred embodiment, the composition exhibits gel-sol thermoreversibility, micelle formation under gelling conditions, optically compatible, controllable surfactant properties, molecular sieving properties and biocompatibility. Further aspects of the invention provide (a) a support matrix composition comprising a block polymer, fluorescent beads and/or a dye for use in the manipulation, processing or analysis of particles, (b) a multichamber plate coated in a support matrix composition and (c) kits for producing the same.

L'invention concerne l'utilisation d'une composition comportant un polymère séquencé comme matrice support pour la manipulation, le traitement ou l'analyse de particules telles que des cellules ou des perles fluorescentes. Dans un mode de réalisation préféré, la composition présente une thermoréversibilité gel-sol, une formation de micelles dans des conditions gélifiantes, des propriétés tensioactives contrôlables et optiquement compatibles, des propriétés de criblage moléculaire et une biocompatibilité. Dans d'autres modes de réalisation, l'invention permet de réaliser une composition de matrice support contenant un polymère séquencé, des perles fluorescentes et/ou un colorant pour la manipulation, le traitement ou l'analyse de particules, ainsi qu'une plaque à plusieurs cavités enrobée d'une composition de matrice support, et des kits de production associés.

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