Gelatin-encapsulated digoxin solutions and method of...

Details Gelatin-encapsulated digoxin solutions and method of... Gelatin-encapsulated digoxin solutions and method of...

A - Human Necessities

61

J

167/154, 167/199

A61J 3/07 (2006.01) A61K 9/48 (2006.01) A61K 31/705 (1980.01)

Patent

CA 1057660

Abstract Digoxin solutions are disclosed which are compatible with gelatin and which are of relatively high concentration, thereby permitting encapsulation of therapeutic amounts of digoxin in soft gelatin capsules of moderate size. The digoxin is first micronized and then dissolved in a vehicle consisting predominately of polyethylene glycol having a molecular weight no greater than about one thousand and having a melting temperature no greater than about 35 degrees C., to provide a digoxin concentration of at least one-half milligram per milliliter and preferably one milligram per milliliter. Solution composed of various solvent blends are disclosed, including solutions which are highly viscous (semi-solid) at room temperature.

235629

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