Geldanamycin compounds and method of use

Details Geldanamycin compounds and method of use Geldanamycin compounds and method of use

A - Human Necessities

61

K

A61K 31/7052 (2006.01) A61K 31/33 (2006.01) A61K 31/675 (2006.01)

Patent

CA 2563979

Geldanamycin compounds having a structure according to formula (I) where Q1, L, L1, R5, R6 and R11 are as defined herein, are useful for treating a disease or disorder ameliorated by inhibiting the function of extracellular heat shock protein-90.

La présente invention se rapporte à des composés de geldanamycine, qui sont représentés par la formule (I), dans laquelle Q?1¿, L, L?1¿, R?5¿, R?6¿ et R?11¿ sont tels que définis dans le descriptif de l'invention. Les composés selon l'invention sont utiles pour traiter une maladie ou un trouble atténués par l'inhibition de la fonction de la protéine de choc thermique 90.

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