Gelified microspheres, method of preparation and applications

Details Gelified microspheres, method of preparation and applications Gelified microspheres, method of preparation and applications

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 9/127 (2006.01) A61K 9/51 (2006.01)

Patent

CA 2187551

Microspheres comprising a gelified polar core which is optionally surrounded by concentric and alternating superimposed <u>n</u> lipidic bilayers or <u>n</u> aqueous liquid layers and <u>n</u> gelified polar layers, <u>n</u> being an integer. The microspheres of the invention are obtainable by delipidation of liposomes designated as liposomes having a gelified polar core, of the type comprising at least one outer lipidic bilayer and at least one inner polar aqueous phase containing a gelified substance.

Lesdites microsphères comprennent un noyau polaire gélifié autour duquel sont, éventuellement, superposées concentriquement et alternativement n bicouches lipidiques ou n couches aqueuses à l'état liquide et n couches polaires gélifiées, n étant un nombre entier et sont susceptibles d'être obtenues par délipidation de liposomes, du type comportant au moins une bicouche lipidique externe et au moins une phase polaire aqueuse interne contenant une substance gélifiée, dénommés liposomes à noyau polaire gélifié.

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