C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 493/08 (2006.01) A61K 31/41 (2006.01) A61K 31/44 (2006.01) A61K 31/55 (2006.01)
Patent
CA 2081679
HA595 Abstract GEM-DIALKYL-7-OXABICYCLOHEPTYL SUBSTITUTED HETEROCYCLIC AMIDE PROSTAGLANDIN ANALOGS USEFUL IN THE TREATMENT OF THROMBOTIC AND VASOSPASTIC DISEASE Gem-dialkyl-7-oxabicycloheptane substituted prostaglandin analogs useful in treating thrombotic and vasospastic disease have the structural formula Image wherein m is 1, 2 or 3; n is 0, 1, 2, 3 or 4; Z is -(CH2)2-, -CH=CH- or Image with the proviso when Z is -CH=CH-, n is 1, 2, 3 or 4; R is CO2H, CO2lower alkyl, or CO2alkali metal, X is O or NH; and where R1 and R2 are as defined herein and R3 and R4 are each independently alkyl, or R3 and R4 may be taken together with the carbon to which it is attached to form a 3- or 4-membered ring.
Misra Raj N.
Osler Hoskin & Harcourt Llp
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