Gem-dihalo and tetrahalo-1,12-diamino-4, 9-diaza-dodecanes

C - Chemistry – Metallurgy – 07 – C

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260/607.5

C07C 211/15 (2006.01)

Patent

CA 1274547

ABSTRACT This invention relates to 2,2-dihalo-1,4-diamino- butanes and salts thereof which are useful as intermed- iates in the preparation of a gem-dihalo or tetrahalo- 1,12-diamino-4,9-diazadodecane compound of the formula: Image wherein X and Y represent hydrogen or halogen, with the proviso that in the case of a dihalo compound both halo- gens are present on one carbon atom, and in the case of a tetrahalo compound the compound is 2,2,11,11-halo- substituted, or a pharmaceutically acceptable salt thereof, the halogen being selected from chloro and fluoro. The gem-dihalo and tetrahalo compounds are themselves useful as antiproliferative or antitumor agents.

615543

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