C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/607.5
C07C 211/15 (2006.01)
Patent
CA 1274547
ABSTRACT This invention relates to 2,2-dihalo-1,4-diamino- butanes and salts thereof which are useful as intermed- iates in the preparation of a gem-dihalo or tetrahalo- 1,12-diamino-4,9-diazadodecane compound of the formula: Image wherein X and Y represent hydrogen or halogen, with the proviso that in the case of a dihalo compound both halo- gens are present on one carbon atom, and in the case of a tetrahalo compound the compound is 2,2,11,11-halo- substituted, or a pharmaceutically acceptable salt thereof, the halogen being selected from chloro and fluoro. The gem-dihalo and tetrahalo compounds are themselves useful as antiproliferative or antitumor agents.
615543
Gerhart Fritz
Mamont Pierre
Merrell Dow Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
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