Gem-diphosphonic acids, a process for the preparation...

Details Gem-diphosphonic acids, a process for the preparation... Gem-diphosphonic acids, a process for the preparation...

C - Chemistry, Metallurgy

07

F

C07F 9/38 (2006.01) A61K 31/66 (2006.01) C07F 9/40 (2006.01) C07F 9/564 (2006.01)

Patent

CA 2067191

2067191 9105791 PCTABS00005 Diphosphonic acids of formula (I), wherein R1 and R2 are hydrogen or C1-C4 alkyl; (A) is hydrogen, halogen, hydroxy or C1-C12 alkyl; (B) is a bond, a C1-C8 alkylene chain, a cycloalkylalkylene chain, an alkylene chain substituted by cyclohexyl or cyclopentyl groups, or an aralkyl chain, an alkyl chain containing an heteroatom (O, S or N-CH3) or an ureido residue -(CH2)n1-NHCONH -(CH2)n- with n ranging from 1 to 5, R3 is hydrogen, C1-C9 alkyl, C3-C6 cycloalkyl, benzyl, phenyl or p-methoxybenzyl; (C) is C1-C5 alkyl, phenyl or an aralkyl chain; R4 is hydrogen, C1-C4 alkyl or an amino group optionally substituted by alkyl, phenyl, benzyl, p-methoxybenzyl, acyl, amminoacidic or peptide groups; R5 and R6 are 2-haloethyl or together form a 1-aziridinyl residue, are useful as antitumor agent.

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