C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/052 (2006.01) A61K 31/395 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61K 31/527 (2006.01) A61P 35/00 (2006.01) C07D 239/70 (2006.01) C07D 471/04 (2006.01) C07D 471/10 (2006.01) C07D 491/107 (2006.01) C07D 491/147 (2006.01) C07D 491/20 (2006.01) C07D 491/22 (2006.01)
Patent
CA 2719538
Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are gem-disubstituted or spirocyclic pyridine, pyrimidine and triazine derivatives.
L'invention porte sur des composés, des compositions pharmaceutiques et des procédés qui sont utiles dans le traitement de troubles à médiation par CDK4, tels que le cancer. Les composés selon l'invention sont des dérivés de pyridine, pyrimidine et triazine disubstitués par GEM ou spirocycliques.
Connors Richard V.
Dai Kang
Eksterowicz John
Fan Pingchen
Fisher Benjamin
Amgen Inc.
Gowling Lafleur Henderson Llp
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