Gem-substituted .alpha. v .beta. 3 integrin antagonists

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 213/74 (2006.01) A61K 31/4427 (2006.01) A61K 31/553 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) C07D 213/73 (2006.01) C07D 401/12 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2419699

The present invention relates to a class of compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of Formula (I), and methods of selectively inhibiting or antagonizing the .alpha.v.beta.3 and/or the .alpha.v.beta.5 integrin.

Cette invention se rapporte à une classe de composés représentés par la formule (I) ou à un sel de ces composés acceptable sur le plan pharmaceutique, à des compositions pharmaceutiques comprenant ces composés représentés par la formule (I) et à des procédés servant à produire sélectivement un effet inhibiteur ou antagoniste contre l'intégrine .alpha.¿v?.beta.¿3? et/ou l'intégrine .alpha.¿v?.beta.¿5?.

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