Gem substituted hydroxamic acids

Details Gem substituted hydroxamic acids Gem substituted hydroxamic acids

C - Chemistry, Metallurgy

07

D

C07D 309/10 (2006.01) A61K 31/351 (2006.01) A61K 31/382 (2006.01) A61K 31/4422 (2006.01) A61K 31/445 (2006.01) A61K 31/453 (2006.01) A61K 31/4709 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01) A61P 19/02 (2006.01) A61P 35/00 (2006.01) C07D 211/60 (2006.01) C07D 335/02 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2342271

Disclosed are novel compounds of the formula: (see formula I) (wherein X is O, S, SO, SO2 or NR3; Z is -OR11, -NR12R13 or optionally substituted alkyl; Q is alkyl, aryl, heterocycle or the like; and R1, R2, R3, R4, R5, R6, R7, R8, R11, R12 and R13 are each H, alkyl or the like), useful in the treatment of arthritis, cancer, and other diseases involving the dysregulated production/release of reprolysins such as Aggrecanase and other diseases characterized by matrix metalloproteinase activity. In addition, the compounds may be used in combination therapy with standard non-steroidal anti- inflammatory drugs (NSAID's), COX-2 inhibitors and analgesics, and in combination with cytotoxic drugs such as adriamycin, daunomycin, cis-platinum, etoposide, taxol, taxotere and other alkaloids, such as vincristine, in the treatment of cancer.

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