Gemcitabine derivatives nanoparticles

Details Gemcitabine derivatives nanoparticles Gemcitabine derivatives nanoparticles

C - Chemistry, Metallurgy

07

H

C07H 19/073 (2006.01) A61K 31/706 (2006.01)

Patent

CA 2572380

The invention concerns a 2',2'-difluoro-2'-deoxycytidine derivative of general formula (I), wherein: R1, R2 and R3, identical or different, represent independently of one another, a hydrogen atom or an at least C18 hydrocarbon acyl radical and of such conformation that it is capable of providing said compound of general formula (I), a compacted form in a polar solvent medium, at least one of groups R1, R2 and R3 being other than a hydrogen atom.

La présente invention concerne un dérivé de 2',2'-difluoro-2'-désoxycytidine de formule générale (I) : dans laquelle : R1, R2 et R3, identiques ou différents, représentent, indépendamment l'un de l'autre, un atome d'hydrogène ou un radical acyle hydrocarboné au moins en C18 et de conformation telle qu'il est capable de conférer audit composé de formule générale (I), une forme compactée dans un milieu solvant polaire, l'un au moins des groupements R1, R2 et R3 étant différent d'un atome d'hydrogène.

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