C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/593.1, 260/2
C07D 295/08 (2006.01) C07C 17/10 (2006.01) C07C 47/453 (2006.01) C07C 215/38 (2006.01) C07C 215/40 (2006.01) C07C 217/74 (2006.01) C07C 291/02 (2006.01) C07D 295/084 (2006.01)
Patent
CA 1109066
A B S T R A C T New geminally disubstituted indenes are of general formula I Image (I) wherein each of R1 and R2 is hydrogen or R1 and R2 together form a direct bond or an alkylene group -(CH2)n-, in which n is an integer from 1 to 4, R3 is hydrogen, C1-3-alkoxy or halogen, and each of R4 and R5 is hydrogen or C1-4-lower alkyl, or R4 and R5 together form an alkylene group -(CH2)m-, in which m is an integer from 3 to 6; and the corresponding amine oxides, quaternary ammonium compounds and salts with physiologically acceptable acids. The indenes find use in treating incontinence, as a mucous membrane decongestant, as a blood pressure reducing agent, as a vasoconstrictor or as an anti- reserpine agent. The indenes may be prepared by processes known per se involving (a) synthesising the side chain -CH(OH)CH2NR4R5 by a method known per se in an indenyl precursor of a formula I compound in which the side chain is incomplete or (b) introducing the double bond into an indanyl precursor of a formula I compound in which the double bond is absent or (c) releasing the terminal amino group in a precursor of a formula I compound in which the terminal amino group is protected.
308533
Joensson Aake N.
Kempe Tomas G.
Mikiver Lembit
Sparf Bengt A.
Ab Kabi
Marks & Clerk
LandOfFree
Geminally disubstituted indene derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Geminally disubstituted indene derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Geminally disubstituted indene derivatives will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-159376