Geminally substituted thiaheterocyclic carboxylic acids and...

Details Geminally substituted thiaheterocyclic carboxylic acids and... Geminally substituted thiaheterocyclic carboxylic acids and...

C - Chemistry, Metallurgy

07

D

167/233, 167/242

C07D 275/02 (2006.01) A61K 31/38 (2006.01) A61K 31/425 (2006.01) C07D 333/48 (2006.01) C07D 409/10 (2006.01) C07D 417/10 (2006.01) C07F 7/08 (2006.01)

Patent

CA 2016464

HA468 Abstract GEMINALLY SUBSTITUTED THIAHETEROCYCLIC CARBOXYLIC ACIDS AND DERIVATIVES THEREOF Novel thromboxane receptor antagonists are disclosed, having the formula I Image wherein: A is aryl, optionally substituted with halogen, lower alkoxy, carboalkoxy, lower alkyl, alkylamino, or phenyl; X is -CH2 or -NH; R1 is COOH, COO-alkali metal (such as Na, K, or Li), COO-lower alkyl, CONHSO2R2, or 5-tetrazolyl; R2 is lower alkyl or aryl; m is 0, 1, or 2; and p is 2, 3, 4 or 5. Also disclosed are novel intermediates of formula I compounds.

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