Gender selection with the use of antibodies

Details Gender selection with the use of antibodies Gender selection with the use of antibodies

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 35/52 (2006.01) A61K 39/395 (2006.01) A61P 15/00 (2006.01) C07K 14/705 (2006.01) C12P 21/08 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2568512

Epitope polypeptides, corresponding to antigenic regions of hydrophilic sequences selected from within mammalian gene Y-chromosome protein sequences, have been prepared and used to generate antibodies in vivo. The antibodies have been found to bind preferentially to the Y-chromosomal sperm component in semen. The binding has been found sufficient to decrease motility of such Y-chromosomal sperm component leading to substantial increases in female offspring when using the treated semen in artificial insemination.

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