Gene amplification and overexpression in cancer

Details Gene amplification and overexpression in cancer Gene amplification and overexpression in cancer

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A01N 1/00 (2006.01) C07D 279/00 (2006.01)

Patent

CA 2528529

There are disclosed methods and compositions for the diagnosis, prevention, and treatment of tumors and cancers in mammals, for example, humans, utilizing a gene, which is amplified in many types of cancer. The amplified genes, their expressed protein products and antibodies are used diagnostically or as targets for cancer therapy or as vaccines; they also are used to identify compounds and reagents useful in cancer diagnosis, prevention, and therapy.

La présente invention concerne des procédés et des compositions destinés au diagnostic, à la prévention et au traitement de tumeurs et de cancers chez des mammifères, par exemple chez des humains, compositions dans lesquelles on utilise un gène, qui est amplifié dans de nombreux types de cancers. Les gènes amplifiés, leurs produits protéiniques exprimés et leurs anticorps sont utilisés pour le diagnostic ou comme cibles de thérapie anticancéreuse ou comme vaccins, et ils sont également utilisés pour identifier des composés et des réactifs utiles pour le diagnostic, la prévention et la thérapie du cancer.

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