C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) A61K 31/7088 (2006.01) A61K 38/16 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2479724
There are disclosed methods and compositions for the diagnosis, prevention, and treatment of tumors and cancers in mammals, for example, humans, utilizing the CTSZ and CD24 genes, which are amplified colon cancer and/or ovarian cancer and/or breast cancer genes. The CTSZ and CD24 genes, their expressed protein products and antibodies are used diagnostically or as targets for cancer therapy or vaccine; they also are used to identify compounds and reagents useful in cancer diagnosis, prevention, and therapy.
L'invention concerne des procédés et des compositions de diagnostic, de prévention et de traitement de tumeurs et de cancers chez les mammifères, par exemple chez l'humain, faisant intervenir les gènes CTSZ et CD24, lesdits gènes étant des gènes amplifiés du cancer du colon et/ou du cancer de l'ovaire et/ou du cancer du sein. Les gènes CTSZ et CD24, et les produits protéiques et anticorps exprimés par ces gènes sont utilisés pour le diagnostic, en tant que cibles pour la thérapie du cancer, en tant que vaccins, et pour identifier des composés et des réactifs servant au diagnostic, à la prévention et à la thérapie du cancer.
Li Jing
Powers Scott
Yang Jianxin
Amgen Inc.
Mbm Intellectual Property Law Llp
Tularik Inc.
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