Gene clone for the human dopamine d1 receptor

C - Chemistry – Metallurgy – 12 – N

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195/1.235

C12N 15/12 (2006.01)

Patent

CA 2024096

Form 24 [GENE CLONE FOR THE HUMAN DOPAMINE D1 RECEPTOR] ABSTRACT Biological receptors for dopamine are presently classified into two types, termed D1 and D2. The D1 receptor is defined as the protein on which dopamine acts to stimulate the enzyme adenylate cyclase; this latter enzyme is inhibited when dopamine acts on D2. D1 and D2 are targets of drug therapy in psychomotor illnesses such as Parkinson's disease, schizophrenia, and drug addiction. We here report and patent the D1 receptor gene and its sequence of nucleotide bases. The D1 protein which is made by this gene has 446 amino acids. The D1 gene contains regions {susceptible to restriction enzymes, particularly EcoR1}which differ between humans, making this D1 gene helpful for future studies attempting to link or associate the gene with various human diseases.

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