Gene coding for a protein regulating aureobasidin sensitivity

Details Gene coding for a protein regulating aureobasidin sensitivity Gene coding for a protein regulating aureobasidin sensitivity

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) C07H 21/00 (2006.01) C07K 14/37 (2006.01) C07K 14/39 (2006.01) C07K 14/395 (2006.01) C07K 14/40 (2006.01) C07K 16/14 (2006.01) C12N 15/11 (2006.01) C12P 21/02 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2124034

[Object] To provide a protein regulating the sensitivity to an antimycotic aureobasidin, a gene coding for this protein, the use thereof, an antibody for the protein and the use thereof. [Constitution] An isolated gene coding for a protein regulating aureobasidin sensitivity. A process for cloning the gene with the use of the gene or a part of the same as a probe. A nucleic acid probe being hybridizable with the gene. An antisense DNA or RNA of the gene. A recombinant or transformant having the gene contained therein. An isolated protein regulating aureobasidin sensitivity and a process for producing the same by using the transformant. An antibody for the protein. A process for detecting the protein or the gene. A process for screening an antimycotic by using the protein or the transformant. [Effects] Useful in the diagnosis and treatment for diseases including mycoses.

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