Gene delivery formulations and methods for treatment of...

Details Gene delivery formulations and methods for treatment of... Gene delivery formulations and methods for treatment of...

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61K 47/34 (2006.01) A61P 9/10 (2006.01) C07K 14/475 (2006.01) C12N 15/85 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2426582

The present inventors have developed a novel approach for efficient delivery of angiogenic factors to the cardiac and peripheral vasculature that avoids problems with toxicity inherent to existing delivery technologies. Vectors carrying coding sequences for Del-1 or VEGF, or both, can be formulated with poloxamers or other polymers for delivery into ischemic tissue and delivered to the heart by retrograde venous perfusion.

La présente invention concerne une nouvelle approche pour une diffusion efficiente de facteurs angiogéniques dans le système vasculaire cardiaque et périphérique, qui évite les problèmes de toxicité inhérents aux techniques de diffusion existantes. Des vecteurs transportant des séquences de codage pour Del-1 et/ou VEGF peuvent être préparés avec des poloxamères ou autres polymères aux fins de diffusion dans un tissu ischémique, et diffusés dans le coeur par perfusion veineuse rétrograde.

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