C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/00 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/00 (2006.01) C12N 15/63 (2006.01) A01K 67/027 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2555340
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO227, PRO233, PRO238, PRO1328, PRO4342, PRO7423, PRO10096, PRO21384, PRO353 or PRO1885 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
La présente invention a trait à des animaux transgéniques, ainsi qu'à des compositions et des procédés associés à la caractérisation de la fonction génétique. De manière spécifique, la présente invention a trait à des souris transgéniques comportant des disruptions dans des gènes PRO227, PRO233, PRO238, PRO1328, PRO4342, PRO7423, PRO10096, PRO21384, PRO353 ou PRO1885. De telles études et caractérisations in vivo peuvent fournir une identification intéressante et une découverte de thérapeutique et/ou de traitement utiles dans la prévention, l'amélioration ou la correction de maladies ou de dysfonctionnements associés aux disruptions géniques telles que des troubles neurologiques ; des troubles cardio-vasculaires, endothéliaux ou angiogénétiques ; des anomalies oculaires ; des troubles immunologiques ; des troubles oncologiques ; des anomalies ou troubles métaboliques osseux ; des troubles métaboliques lipidiques ; ou de anomalies développementales.
Edwards Joel
Huang Wenhu
Montgomery Charles A.
Qian Ni Nancy
Shi Zheng-Zheng
Lexicon Genetics Incorporated
Lexicon Pharmaceuticals Inc.
Smart & Biggar
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