Gene disruptions, compositions and methods relating thereto

Details Gene disruptions, compositions and methods relating thereto Gene disruptions, compositions and methods relating thereto

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) A01K 67/027 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 49/00 (2006.01) C07K 16/18 (2006.01) C12N 15/09 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) C07K 14/47 (2006.01) C12N 15/12 (2006.01) C12N 15/85 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2619577

The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

L'invention concerne des animaux transgéniques, des compositions et des procédés relatifs à la caractérisation de fonction génique. Plus précisément, l'invention concerne des souris transgéniques comprenant des disruptions dans les gènes PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 ou PRO85161. De telles études et caractérisations in vivo permettent d'identifier et de découvrir des agents thérapeutiques et/ou traitements utiles dans la prévention, l'amélioration ou la correction de maladies ou de dysfonctionnements associés à des disruptions géniques, tels que des troubles neurologiques; des troubles cardio-vasculaires, endothéliaux ou angiogéniques; des anomalies oculaires; des troubles immunologiques; des troubles oncologiques; des anomalies ou troubles métaboliques osseux; des troubles métaboliques lipidiques; ou des troubles de croissance.

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