C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12P 21/02 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2344576
This invention provides isolated nucleic acids encoding a motor neuron restricted MNR2 protein, and a homeobox HB9 protein. Also provided are purified MNR2 and HB9 proteins, antibodies recognizing these proteins, transgenic animals expressing these proteins, and functionally equivalent analogs of these proteins. Finally, methods are disclosed for inducing differentiation of somatic motor neurons, and for treating diseases related to a lack of normally functioning motor neurons, neurodegenerative diseases, acute nervous system injury, and neuromuscular disease.
L'invention concerne des acide nucléiques isolés codant pour une protéine MNR2 à motoneurones restreints et une protéine HB9 à homéoboîte. L'invention concerne également des protéines MNR2 and HB9 purifiées, des anticorps reconnaissant ces protéines, des animaux transgéniques exprimant ces protéines et des analogues fonctionnellement équivalents de ces protéines. L'invention concerne enfin des méthodes permettant d'induire la différenciation de motoneurones somatiques et de traiter des maladies liées à la carence en motoneurones fonctionnant normalement, des maladies neurodégénératives, des troubles neurologiques et des maladies neuromusculaires.
Jessell Thomas M.
Tanabe Yasuto
William Christopher
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
The Trustees Of Columbia University In The City Of New York
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