Gene encoding promoter domain of tumor suppressor gene p51...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/10 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2377438

A gene encoding the promoter domain of a protein p51 which is capable of inducing cell death; and a gene encoding the 5'-nontranslation domain of p51. These genes are useful in diagnosing and treating diseases typified by cancer caused by abnormal regulation of cell proliferation. Antisense DNAs and antisense RNAs of these genes; nucleic acid probes comprising the full sequences of these genes or parts thereof; a method for detecting the above genes or genes analogous thereto by using these nucleic acid probes; transformants having the above genes transferred thereinto; a method for screening a drug by using the same; and the like. These genes are also useful in diagnosing and treating diseases such as cancer.

L'invention concerne un gène codant le domaine promoteur d'une protéine p51 capable d'induire la mort cellulaire; et un gène codant le domaine de non traduction 5' de ladite protéine. Ce type de gène est utile pour le diagnostic et le traitement des maladies dont l'exemple type est le cancer issu d'une régulation anormale de la prolifération cellulaire. L'invention concerne en outre des ADN et ARN antisens du type de gène considéré; des sondes d'acide nucléique renfermant les pleines séquences des gènes en question ou des séquences partielles; un procédé de détection de ces gènes ou de leurs analogues par le biais des sondes susmentionnées; des transformants auxquels lesdits gènes ont été intégrés; un procédé de criblage de médicament par le biais de ces transformants; et autres éléments. Par ailleurs, les gènes décrits sont utiles pour le diagnostic et le traitement de maladies comme le cancer.

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