Gene expression during meningococcus adhesion

Details Gene expression during meningococcus adhesion Gene expression during meningococcus adhesion

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/095 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 31/04 (2006.01) C07K 14/22 (2006.01) C07K 16/12 (2006.01) C12N 1/21 (2006.01) C12N 15/10 (2006.01) C12N 15/11 (2006.01) C12Q 1/02 (2006.01) C12Q 1/04 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2448284

The first step in human meningococcal infection involves adhesion to the epithelial cells of the nasopharynx tract. The invention provides various methods and compounds for preventing the attachment of Neisserial cells to epithelial cells and is based on the identification of 347 meningococcal genes which play a role in the adhesion process.

La première étape de l'infection à méningocoques chez l'homme implique l'adhésion aux cellules épithéliales du tractus nasopharyngé. L'invention a pour objet divers procédés et composés permettant de prévenir la fixation des cellules de Neisser aux cellules épithéliales. Ces procédés se fondent sur l'identification des gènes méningococciques 347 qui jouent un rôle dans ce processus d'adhésion.

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