Gene expression in breast cancer

Details Gene expression in breast cancer Gene expression in breast cancer

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 31/7105 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2519630

The invention features nucleic acids encoding proteins that are expressed at a higher or a lower level in breast cancer cells than in normal breast cells or in a cell of one grade or stage of breast cancer than in a cell of another grade or stage of breast cancer. The invention also includes proteins encoded by the nucleic acids, vectors containing the nucleic acids, and cells containing the vectors. In another aspect, the invention features methods of diagnosing and treating breast cancers of various grades and stages.

Cette invention a trait à des acides nucléiques codant des protéines à plus fort ou plus faible niveau d'expression dans le cancer du sein, par rapport à celui des cellules mammaires normales ou dans une cellule à un certain stade d'évolution de ce type de cancer par rapport à celui d'un autre stade. Elle porte également sur des protéines codées par ces acides nucléiques, sur des vecteurs contenant ces acides et sur des cellules contenant ces vecteurs. Un autre volet de l'invention concerne des méthodes diagnostiques et thérapeutiques du cancer du sein à différents stades d'évolution.

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