Gene expression markers for response to egfr inhibitor drugs

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01)

Patent

CA 2515096

The present invention concerns prognostic markers associated with cancer. In particular, the invention concerns prognostic methods based on the molecular charaterization of gene expression in paraffin-embedded, fixed samples of cancer tissue, which allow a physician to predict whether a patient is likely to respond well to treatment with an EGFR inhibitor.

La présente invention porte sur des marqueurs prédictifs associés au cancer. L'invention porte notamment sur des procédés prédictifs basés sur la caractérisation moléculaire de l'expression génique dans des échantillons de tissu cancéreux fixés, noyés dans une paraffine, et qui permettent au médecin de prévoir si le patient est susceptible de bien réagir au traitement avec un inhibiteur de EGFR.

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