Gene expression profiles associated with lean phenotype and...

C - Chemistry – Metallurgy – 40 – B

Patent

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C40B 40/08 (2006.01) G06F 19/28 (2011.01) C07H 21/00 (2006.01) C12Q 1/68 (2006.01) C40B 30/04 (2006.01) C40B 40/06 (2006.01) C40B 40/10 (2006.01) G01N 33/543 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2734510

Gene expression profiles associated with improved or maintained lean body mass or reduced body fat are dis-closed. The gene expression profiles were determined in adipose, liver, and muscle tissue of animals subjected to lean-promoting regimens such as consumption of a high protein diet, ingestion of conjugated linolenic acid, and/or increased exercise. Methods of using such profiles for the identification of pharmaceutical substances, nutraceutical substances, dietary substances, or treatment regimens that modulate or contribute to desired phenotypes in animals are also disclosed

Linvention concerne des profils dexpression génique associés avec lamélioration ou le maintien dune masse corporelle faible ou dune masse adipeuse corporelle réduite. Les profils dexpression génique sont déterminés dans ladipose, le foie et le tissu musculaire danimaux soumis à des régimes amaigrissants tels que la consommation dun régime à teneur élevée en protéines, lingestion dacide linolénique conjugué et/ou une augmentation de lexercice physique. Linvention concerne également des procédés dutilisation de tels profils pour lidentification de substances pharmaceutiques, de substances nutraceutiques, de substances diététiques ou de régimes de traitement qui modulent ou contribuent à des phénotypes souhaités chez des animaux.

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