C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 38/18 (2006.01) C07H 21/04 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2433436
The present invention identifies genes whose expression pattern is altered when precursor stem cells undergo differentiation into osteoblasts. The genes identified may be used as markers for the differentiation process. The present invention also provides methods to screen agents that are capable of modulating the differentiation process. The present invention also provides methods of identifying therapeutic agents that stimulate bone information by analyzing the expression of one or more of the genes identified.
L'invention concerne des gènes dont le modèle d'expression change lorsque des précurseurs embryonnaires subissent une différenciation ostéoblastique. Les gènes identifiés peuvent être utilisés comme marqueurs pour le processus de différenciation. La présente invention porte aussi sur des procédés pour le criblage d'agents aptes à moduler ce processus de différenciation. Ladite invention concerne également des procédés pour identifier des agents thérapeutiques qui stimulent la formation osseuse, selon lesquels on analyse l'expression d'un ou de plusieurs gènes identifiés.
Axelrod Douglas W.
Cook Jonathan S.
Darren Ji
Einstein Richard
Houghton Adam
Deeth Williams Wall Llp
Gene Logic Inc.
The Procter & Gamble Company
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