Gene expression profiling for identification, monitoring,...

Details Gene expression profiling for identification, monitoring,... Gene expression profiling for identification, monitoring,...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2728537

A method is provided in various embodiments for determining a profile data set for a subject with osteoarthritis or conditions related to osteoarthritis based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification for measuring the amount of RNA corresponding to at least one constituent from Tables 1-2, 4-6, and 8. The profile data set comprises the measure of each constituent, and amplification is performed under measurement conditions that are substantially repeatable.

Selon divers modes de réalisations, la présente invention concerne un procédé permettant la détermination dun ensemble de données de profil pour un sujet souffrant de larthrose ou de conditions associées à larthrose sur la base dun échantillon prélevé du sujet, léchantillon fournissant une source dARN. Le procédé comprend lamplification pour mesurer la quantité dARN correspondant à au moins un constituant des Tables 1-2, 4-6, et 8. Lensemble de données de profil comporte la mesure de chaque constituant, et lamplification est effectuée dans des conditions de mesure qui sont sensiblement reproductibles.

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