Gene expression profiling for the identification,...

Details Gene expression profiling for the identification,... Gene expression profiling for the identification,...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2748823

A method is provided in various embodiments for determining a profile data set for a subject with prostate cancer or a condition related to prostate cancer based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification for measuring the amount of RNA corresponding to at least 1 constituent from Table 1 and/or Table 8 in conjunction with PSA. The profile data set comprises the measure of each constituent, and amplification is performed under measurement conditions that are substantially repeatable.

L'invention porte sur un procédé comportant divers modes de réalisation pour déterminer un ensemble de données de profil pour un sujet présentant un cancer de la prostate ou un état apparenté au cancer de la prostate sur la base d'un échantillon provenant du sujet, l'échantillon fournissant une source d'ARN. Le procédé comprend l'utilisation d'une amplification pour mesurer la quantité d'ARN correspondant à au moins 1 constituant provenant du Tableau 1 et/ou du Tableau 8 conjointement avec l'antigène prostatique spécifique (APS). Les ensembles de données de profil comprennent la mesure de chaque constituant, et une amplification est effectuée dans des conditions de mesure qui sont sensiblement répétitibles.

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