Gene expression profiling in biopsied tumor tissues

Details Gene expression profiling in biopsied tumor tissues Gene expression profiling in biopsied tumor tissues

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12N 15/10 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2478850

The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. Th invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.

L'invention concerne des procédés sensibles permettant de mesurer des teneurs de mARN dans des tissus tumoraux ponctionnés, y compris le matériau de biopsie archivé, encastré dans la paraffine. L'invention concerne également des séries géniques de cancer du sein, importantes dans le diagnostic et le traitement du cancer du sein, ainsi que des procédés permettant d'allouer le traitement le plus optimal à des patientes ayant un cancer du sein, sur la base de connaissances provenant d'études d'expression génique.

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