Gene expression profiling of egfr positive cancer

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) C07H 21/04 (2006.01)

Patent

CA 2506066

The present invention concerns prognostic markers associated with EGFR positive cancer. In particular, the invention concerns prognostic methods based on the molecular characterization of gene expression in paraffin- embedded, fixed tissue samples of EGFRexpressing cancer, which allow a physician to predict whether a patient is likely to respond well to treatment with an EGFR inhibitor.

La présente invention a trait à des marqueurs de pronostic associés au cancer à récepteur de facteur de croissance épidermique. En particulier, l'invention a trait à des procédés de pronostic basés sur la caractérisation moléculaire de l'expression génétique dans des échantillons tissulaires de cancer d'expression de récepteur de facteur de croissance épidermique inclus dans la paraffine, qui permettent au physicien de prédire si le patient est susceptible d'une réaction appropriée à un traitement réalisé avec un inhibiteur du récepteur de facteur de croissance épidermique.

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