Gene expression profiling of inflammatory bowel disease

Details Gene expression profiling of inflammatory bowel disease Gene expression profiling of inflammatory bowel disease

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2356207

The present invention relates to methods for identifying and/or classifying patients with inflammatory bowel diseases (IBD), particularly patients with Crohn's disease or ulcerative colitis. Gene expression profiling shows broad and fundamental differences in the pathogenic mechanism of UC and CD. The subject method is based on the findings that certain genes are differentially expressed in intestinal tissue of IBD patients compared with related normal cells, such as normal colon cells. That change can be used to identify or classify IBD cells by the upregulation and/or downregulation of expression of particular genes, alterations in protein levels or modification, or changes at the genomic level (such as mutation, methylation, etc), e.g., an event which is implicated in the pathology of inflammatory bowel diseases.

La présente invention concerne des procédés d'identification et/ou de classification de patients souffrant d'affections intestinales inflammatoires (IBD), et notamment de patients souffrant de la maladie de Crohn ou d'une rectocolite hémorragique. Le profilage de l'expression génétique permet de soulever des différences importantes et fondamentales de mécanisme pathogénique entre ces deux dernières maladies. Le procédé de cette invention se fonde sur des découvertes révélant que certains gènes sont exprimés de manière différentielle dans le tissu intestinal de patients souffrant d'affections de type IBD, par comparaison avec certaines cellules normales associées, telles que les cellules du côlon normales. Ce changement peut servir à identifier ou classifier les cellules IBD par régulation positive et/ou régulation négative de l'expression de gènes particuliers, des altérations de taux de protéines ou de modification de protéines, ou des changements intervenant au niveau du génome (tels que mutation, méthylation, etc.), notamment d'un événement impliqué dans la pathologie des affections intestinales inflammatoires.

Affiliated with

Also associated with

Rating

Gene expression profiling of inflammatory bowel disease does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Gene expression profiling of inflammatory bowel disease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gene expression profiling of inflammatory bowel disease will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1876358