C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2430981
The invention relates to a polynucleotide library useful in the molecular characterization of a carcinoma, the library including a pool of polynucleotide sequences of subsequences thereof wherein the sequences of subsequences are overpressed in tumor cells, further wherein the sequences of subsequences correspond substantially to any of the polynucleotide sequences set forth in any of SEQ ID NOS: 1- 468 or the complement thereof. The invention relates also to polynucleotides arrays useful to differentiate tumor cells from normal cells comprising combinations of selected immobilized polynucleotide sequences sets.
L'invention concerne une banque de polynucléotides utile pour la caractérisation moléculaire d'un carcinome, cette banque comprenant un fonds de séquences polynucléotidiques ou de sous-séquences polynucléotidiques surexprimées dans des cellules tumorales. Ces séquences ou sous-séquences correspondent sensiblement aux séquences polynucléotidiques formulées dans les séquences SEQ ID NOS :1-468 ou leur complément. L'invention concerne également des réseaux polynucléotidiques utiles pour différencier des cellules tumorales par rapport à des cellules saines, comprenant des combinaisons de séries de séquences polynucléotidiques immobilisées.
Bertucci Francois
Birnbaum Daniel
Fert Vincent
Houlgatte Remi
Nguyen Catherine
Gowling Lafleur Henderson Llp
Inserm
Institut Paoli Calmettes
Ipsogen
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