Gene for peripheral arterial occlusive disease

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/12 (2006.01) A01K 67/027 (2006.01) C07K 14/72 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2474759

A role of the human PAOD1 gene, a. k. a. prostaglandin E receptor subtype EP3 or PTGER3, in peripheral arterial occlusive disease is disclosed, as are nucleic acids encoding several subtypes of the receptor comprising novel exons 4 and 5. Methods for diagnosis, prediction of clinical course and treatment for peripheral occlusive disease using polymorphisms in the PAOD1 gene are also disclosed.

L'invention concerne le rôle du gène PAOD1 humain dans la maladie occlusive artérielle périphérique. L'invention concerne également des méthodes de diagnostic, de pronostic clinique et de traitement de la maladie occlusive artérielle périphérique au moyen de polymorphismes dans le gène PAOD1.

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