Gene functional analysis and discovery using randomized or...

Details Gene functional analysis and discovery using randomized or... Gene functional analysis and discovery using randomized or...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12N 15/10 (2006.01) C12N 15/11 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2278734

The present invention provides a hairpin ribozyme library having a randomized recognition sequence, packaged in a vector and operably linked to a promoter suitable for high level expression in a wide variety of cells. The invention comprises using the library in a variety of selection protocols for identifying, isolating and characterizing known or unknown target RNAs, to reveal the phenotypic effects of such cleavage, and to identify the gene products that produce those phenotypic effects.

Cette invention concerne une banque de ribozymes en épingle à cheveux contenant une séquence de reconnaissance rendue aléatoire, qui est intégrée dans un vecteur aléatoire et liée de manière opérationnelle à un promoteur approprié à l'expression de très haut niveau dans une grande diversité de cellules. Cette invention consiste à utiliser la banque dans divers protocoles de sélection pour identifier, isoler et caractériser des ARN cibles connus et inconnus afin de révéler les effets phénotypiques de cette division et d'identifier les produits géniques qui produisent ces mêmes effets phénotypiques.

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