C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12P 21/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2432214
The invention concerns a nucleic acid sequence involved in apoptosis regulation and tumoral reversion of the p53 path, and the protein encoded by said nucleic acid sequence, as well as methods for detecting, identifying and/or screening compounds for use in treating cancers and certain neurodegenerative diseases, related to dysfunction in tumour suppression regulation and/or apoptosis in the biological chain of p53, said methods being based on interaction between TSIP4 and TSIP2.
La pr~sente invention concerne une s~quence d'acide nucl~ique dans la r~gulation de l'apoptose et de la r~version tumorale de la voie de p53, ainsi que la prot~ine cod~e par cette s~quence d'acide nucl~ique, ainsi que des m~thodes de d~tection, identification et/ou criblage de compos~s pouvant notamment Útre utilis~s pour le traitement des cancers ou de certaines maladies neuro-d~g~n~ratives, li~s ~ des d~rglements dans la r~gulation de la suppression tumorale et/ou de l'apoptose, dans la cha¹ne biologique de p53, lesdits proc~d~s ~tant bas~s sur l'interaction entre TSIP4 et TSIP2.
Amson Robert
Passer Brent
Roperch Jean-Pierre
Telerman Adam
Molecular Engines Laboratories
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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