Gene networks for control of gene expression

Details Gene networks for control of gene expression Gene networks for control of gene expression

C - Chemistry, Metallurgy

12

N

C12N 1/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C12N 1/11 (2006.01) C12N 1/19 (2006.01) C12N 1/38 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12N 15/70 (2006.01) C12N 15/74 (2006.01) C12N 15/79 (2006.01) C12N 15/81 (2006.01) C12N 15/82 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2353800

The present invention relates to compositions for regulating gene expression in a cell. In particular, the invention provides composition constructs which switch expression of a gene of interest between stable "on" or "off" states in response to a transiently applied agent. The invention further provides adjustable-threshold switch constructs for expressing a gene of interest in response to the sustained application of an agent at a concentration above or below a desired threshold concentration. The invention also provides multi- state oscillator constructs in which expression of a gene of interest is periodically altered in the absence of administration of agents which are extraneous to the construct. Also provided are methods for using the invention's constructs.

L'invention concerne des compositions destinées à réguler l'expression génétique dans une cellule. Elle concerne notamment des structures de compositions qui commutent l'expression d'un gène d'intérêt entre les états stables "activé" et "désactivé" en réponse à un agent appliqué de façon transitoire. L'invention concerne en outre un seuil réglable d'un agent à des concentrations supérieures ou inférieures à une concentration de seuil désirée. En outre, l'invention concerne des structures d'oscillateur à états multiples dans lesquelles l'expression d'un gène d'intérêt est périodiquement altérée en l'absence d'administration d'agents étrangers à la structure. L'invention concerne enfin des procédés d'utilisation des structures de l'invention.

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