C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 39/05 (2006.01) A61K 39/395 (2006.01) A61P 31/04 (2006.01) C07K 14/34 (2006.01) C07K 16/14 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/00 (2006.01) C12P 21/02 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2458559
It is intended to provide an antigen specific to Corynebacterium diphtheriae which is usable in developing vaccines for protecting/preventing infection with diphtheria. A gene encoding the following protein (a) or (b): (a) a protein comprising the amino acid sequence represented by SEQ ID NO:1 as described below: (SEQ ID NO:1) MFRRSLASLA AVAVISGVVV APANAVTVTV NNMTCTIKLT PEETNFIPLS SPVMLTKEKA AFLKNQYGET QLSALDAEIK KKEKELTELE PNAAGREMLT SELKEKKKRF TANKKFSDAL DACIAGENYD SSKPNGPKDP NGPKKPGDSD QSGGSEKPNG PKDPGGSEKP NDPKHPEVER ALPSTNGAVI GAIVAVLGIL AAALPVIKSI LRALLP; and (b) a protein comprising an amino acid sequence derived from the amino acid (a) by deletion, substitution or addition of one to several amino acids and having a C. diphtheriae antigenic activity.
L'invention concerne un antigène spécifique de Corynebacterium diphteriae servant à développer des vaccins assurant une protection/prophylaxie contre une infection de type diphtérie. L'invention se rapporte en outre à un gène codant pour les protéines (a) ou (b) suivantes : (a) est une protéine comportant la séquence d'acides aminés représentée par SEQ ID NO:1 MFRRSLASLA AVAVISGVVV APANAVTVTV NNMTCTIKLT PEETNFIPLS SPVMLTKEKA AFLKNQYGET QLSALDAEIK KKEKELTELE PNAAGREMLT SELKEKKKRF TANKKFSDAL DACIAGENYD SSKPNGPKDP NGPKKPGDSD QSGGSEKPNG PKDPGGSEKP NDPKHPEVER ALPSTNGAVI GAIVAVLGIL AAAPVIKSI LRALLP, et (b) est une protéine comprenant une séquence d'acides aminés dérivée de la protéine (a) par délétion, substitution, ou addition d'un ou plusieurs acides aminés et présente une activité antigénique dirigée contre Corynebacterium diphteriae.
Japan As Represented By Director-General Of National Institute O
Japan Science And Technology Agency
Ridout & Maybee Llp
LandOfFree
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