C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2675354
The invention provides compositions and methods for determining the likelihood of successful treatment with a pyrimidine based antimetabolite chemotherapy drug and a platinum based chemotherapy drug, such as 5-FU/oxaliplatin. The methods comprise determining the genomic polymorphism present in a predetermined region of a gene of interest and correlating the polymorphism to the predictive response. Patients identified as responsive are then treated with the appropriate therapy.
L'invention concerne des compositions et des méthodes permettant de déterminer la probabilité de réussite de traitement à l'aide d'un médicament chimiothérapeutique antimétabolite à base de pyrimidine et d'un médicament chimiothérapeutique à base de platine, tel que le 5-FU/oxaliplatine. Les méthodes consistent à déterminer le polymorphisme génomique présent dans une région prédéterminée d'un gène d'intérêt et à corréler le polymorphisme avec la réponse prédictive. Des patients identifiés comme sensibles sont ensuite traités à l'aide de la thérapie appropriée.
Lenz Heinz-Josef
Zhang Wu
Smart & Biggar
University Of Southern California
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