Gene polymorphisms as sex-specific predictors in cancer therapy

Details Gene polymorphisms as sex-specific predictors in cancer therapy Gene polymorphisms as sex-specific predictors in cancer therapy

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2675370

The invention provides compositions and methods for determining the likelihood of gender-specific successful treatment with 5-FU/oxaliplatin or an equivalent of each thereof. The methods comprise determining the genomic polymorphism present in a predetermined region of a gene of interest and correlating the polymorphism to the predictive response. Patients identified as responsive are then treated with the appropriate therapy.

L'invention concerne des compositions et des procédés destinés à déterminer la probabilité de traitement réussi propre à chaque sexe avec 5-FU/oxaliplatine ou un équivalent de chacun de ceux-ci. Les procédés comprennent la détermination du polymorphisme génomique présent dans une région prédéterminée d'un gène d'intérêt et la corrélation du polymorphisme à la réponse prédictive. Des patients identifiés comme réactifs sont ensuite traités avec la thérapie appropriée.

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