Gene recombinant antibodies

Details Gene recombinant antibodies Gene recombinant antibodies

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2328986

The present invention relates to a gene recombinant antibody which specifically reacts with human VEGF receptor Flt-1. Also, the present invention relates to a gene recombinant anti-human VEGF receptor Flt-1 antibody having an activity which neutralizes human Flt-1. Furthermore, it provides a method, a diagnostic agent and a therapeutic agent for treating diseases in which their morbid states progress by abnormal angiogenesis, such as proliferation or metastasis of solid tumors, arthritis in chronic rheumatoid arthritis, diabetic retinopathy, retinopathy of prematurity, psoriasis, and the like.

Cette invention a trait à un anticorps recombiné de gène réagissant de manière spécifique avec le récepteur Flt-1 du facteur de croissance endothélial vasculaire humain (VEGF) ainsi qu'à un anticorps recombiné de gène contre le récepteur Flt-1 du VEGF anti-humain. Elle porte également sur une méthode diagnostique, des diagnostics et des médicaments relatifs à une aggravation d'état maladif avec néovascularisation anormale, par exemple prolifération ou métastase de tumeur solide, arthrite dans la polyarthrite rhumatoïde, rétinopathie diabétique, rétinopathie prématurée, psoriasis, etc.

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