Gene screening methods and related assays

Details Gene screening methods and related assays Gene screening methods and related assays

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2325823

The present invention relates to cell death genes, which are genes required for programmed cell death; mutant organisms, in which ectopic programmed cell death occurs in embryos to a greater than normal extent and agents which alter the ability to modulate programmed cell death of cells. A mutant form of Daktl, Daktlq in a Drosophila melanogaster has been identified. Daktl and its mammalian homolog, PKB are known to protect cells from undergoing apoptosis. A genetic screen for identifying genes related to programmed cell death by their ability to interact genetically with the mutant form of Daktl is described.

La présente invention se rapporte aux gènes de la mort cellulaire qui sont des gènes requis pour la mort cellulaire programmée; sur des organismes mutants dans lesquels la mort cellulaire programmée ectopique se produit dans les embryons dans des proportions considérables et sur des agents qui modifient la capacité à moduler la mort cellulaire programmée. Une forme de mutant de Dakt1, Dakt1?q¿, dans un Drosophila melanogaster a été identifiée. L'invention porte également sur un crible destiné à identifier les gènes liés à la mort cellulaire programmée par leur capacité à avoir une interaction génétique avec la forme mutante de Dakt1.

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