Gene sequences encoding modified residues situated in the...

Details Gene sequences encoding modified residues situated in the... Gene sequences encoding modified residues situated in the...

C - Chemistry, Metallurgy

12

N

195/39.1, 195/1.

C12N 15/58 (2006.01) C12N 9/64 (2006.01) C12N 9/72 (2006.01)

Patent

CA 2007364

ABSTRACT There are provided methods for generating novel, modified DNA sequences for encoding modified polypeptides having tissue plasminogen activator (tPA) fibrinolytic-like activity. Preferred embodiments comprise alterations in the protease domain in order to more closely mimic the structures and activity of the urokinase protease domain. IG1-9.0

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